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Human orgasms usually result from physical sexual stimulation of the penis in males typically accompanying ejaculation , and the clitoris in females. The health effects surrounding the human orgasm are diverse. There are many physiological responses during sexual activity, including a relaxed state created by prolactin, as well as changes in the central nervous system such as a temporary decrease in the metabolic activity of large parts of the cerebral cortex while there is no change or increased metabolic activity in the limbic i. Orgasm in non-human animals has been studied significantly less than orgasm in humans, but research on the subject is ongoing. In a clinical context, orgasm is usually defined strictly by the muscular contractions involved during sexual activity, along with the characteristic patterns of change in heart rate, blood pressure, and often respiration rate and depth.

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